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Unmasking High-Risk Breast Tumors

A unique genetic signature can alert physicians to high-risk breast tumors that masquerade as low-risk tumors, according to research at the Siteman Cancer Center and collaborating national cancer centers. Although these tumors appear to be estrogen-receptor-positive – meaning they should depend on the hormone estrogen to grow – they don’t respond well to anti-estrogen therapy. “These tumors are like wolves in sheep’s clothing,” says Matthew Ellis, MB, BChir, PhD, a Washington University medical oncologist at Siteman.

A clinical test for the high-risk gene signature will be widely available soon. The test, Ellis says, will help physicians identify women who would benefit from more aggressive treatment suited to this tumor type.

New Study on Mammography

A new study from Sweden reinforces the argument that women should follow American Cancer Society guidelines of annual mammograms starting at age 40. More in this "Cancer Connection" podcast with Kate Appleton, MD, radiologist at the Joanne Knight Breast Health Center at Siteman Cancer Center.

 

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