For years, blood tests have helped diagnose Alzheimer’s disease, but couldn’t determine the clinical stage of the disease. Now, researchers at WashU Medicine and Lund University in Sweden have developed a blood test that can not only help with diagnosis but also indicate how far the disease has progressed.

There lies a paradox in sleep. Its apparent tranquility juxtaposes with the brain’s bustling activity. The night is still, but the brain is far from dormant. During sleep, brain cells produce bursts of electrical pulses that cumulate into rhythmic waves—a sign of heightened brain cell function. But why is the brain active when we are resting?

Taking a single pill that combines medications targeting cardiovascular disease-related conditions was shown long ago to lower the risk of death from such causes, including heart attacks and strokes. The concept of using such “polypills” to prevent and treat atherosclerotic cardiovascular disease was introduced nearly 25 years ago. Still, many years and a body of supportive research later, use of such pills remains low throughout the world.

Many middle-aged and older women get mammograms every one to two years to screen for breast cancer. When specialists read these mammograms, they assess breast density along with signs of cancer, comparing a woman’s previous mammograms to her most recent one to look for worrisome changes. But some changes are difficult to detect by eye. A study by researchers indicates that previous mammograms hold underutilized data that could help identify women at high risk of breast cancer.

For people who have experienced a heart attack or stroke, taking a daily aspirin has been shown to prevent a second one. Yet, despite aspirin’s low cost and its clear benefits in such scenarios, fewer than half of people worldwide who have had a heart attack or stroke take the medication, according to a new study led by researchers at Washington University School of Medicine in St. Louis and University of Michigan.

A growing pile of evidence indicates that the tens of trillions of microbes that normally live in our intestines—the so-called gut microbiome—have far-reaching effects on how our bodies function. Members of this microbial community produce vitamins, help us digest food, prevent the overgrowth of harmful bacteria and regulate the immune system, among other benefits. Now, a new study suggests that the gut microbiome also plays a key role in the health of our brains, according to researchers from Washington University School of Medicine in St. Louis.

Building on imaging methods long used on the heart, researchers have developed a new technology that can produce 3D maps showing the magnitude and distribution of uterine contractions in real time and across the entire surface of the uterus during labor.

Huntington’s disease, a fatal, inherited neurodegenerative condition, is caused by a genetic error present at birth, though its symptoms often don’t begin until middle adulthood. Scientists at Washington University School of Medicine in St. Louis have been trying to understand how the aging process triggers the onset of symptoms, with the expectation that such knowledge could point to treatments that delay or prevent neurodegeneration.

Current injectable vaccines help prevent severe illness and death but do little to prevent infections, especially as highly contagious newer variants continue to spread. The advantage of the nasal vaccine is that it delivers a boost to immunity in the nose and upper respiratory tract, right where the virus enters the body, thereby potentially preventing infections altogether.

E-cigs were praised as a healthier alternative to cigarettes when they were first invented, but a study looking at dual nicotine use says otherwise.

30% – 50% of older adults have mild sleep apnea: a condition that causes breathing to repeatedly stop and start during sleep. Some people may not have any signs or symptoms of impairment, resulting in increased risks when getting behind a steering wheel.

Antibiotics do not prevent UTIs or future infections. Research shows that they actually can do the opposite by clearing healthy bacteria from the body, making it easier for E.coli to infect the bladder in a poorly diversified gut microbiome.

Solid organ transplant recipients are at high risk for developing severe COVID-19. The immunosuppressive medications that prevent the body from rejecting the new organ can cause the patient to be high-risk for catching all types of infectious diseases.

In a phase 2 clinical trial, researchers at Washington University School of Medicine and the University of Chicago demonstrated that symptoms of depression can improve rapidly following a single, one-hour treatment with inhaled nitrous oxide.

Babies who suffer oxygen deficiencies during birth are at risk of brain damage that can lead to developmental delays, cerebral palsy and even death. To prevent this, most women in labor undergo continuous monitoring of the baby’s heart rate and receive supplemental oxygen if the heart rate is abnormal, with the thought that this common practice increases oxygen delivery to the baby. However, there is conflicting evidence about whether this long-recommended practice improves infant health.

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer’s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise the risk of strokes.

Cancer is most often detected using traditional tissue biopsy: the removal of tissue by needle, endoscope or open surgery. The tissue sample is then examined for the presence of cancer cells. Though the standard of care, this kind of biopsy comes with some limitations. Because the procedure is invasive, it can be risky, and recovery can be uncomfortable. Additionally, such a procedure may not be safe for some people and may not be practical for those needing a series of biopsies to monitor the progress of cancer treatment.

BY JULIA EVANGELOU STRAIT

Researchers at Washington University School of Medicine are establishing an international collaboration that aims to help scientists prepare for the next pandemic and, perhaps, provide insight into the current one.