Heart & Vascular Center

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#14 in the Nation
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Loeys-Dietz Aneurysm Syndrome

Loeys-Dietz syndrome is an autosomal dominant genetic condition which shares some features with Marfan syndrome. However, this disease is associated with a much more aggressive course, with aneurysms and dissections occurring in blood vessels at a relatively small size and at a young age in some individuals. The features of this condition can include:
  • Abnormal shape of the head (craniosynostosis)
  • Wide-set eyes (hypertelorism)
  • Split uvula
  • Cleft palate
  • Curly (tortuous) blood vessels
  • Chest wall deformities (pectus deformities)
  • Scoliosis
  • Club feet
  • Soft and velvety skin
  • Thin skin with easily visible veins
  • Bluish eye whites (sclera)
It is important to make the diagnosis of Loeys-Dietz syndrome as surgery may be required on relatively small aortic blood vessels. Our center has expertise in the evaluation and management of this condition, including valve-sparing aortic root replacement surgery.

Our Marfan Syndrome Clinic has expertise in the multidisciplinary evaluation of patients with Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysm and dissection syndrome, unexplained aortic dissection, vascular Ehlers-Danlos syndrome and other related disorders.

To make an appointment with a Washington University heart or vascular specialist at Barnes-Jewish Hospital, call .

Partner Sites

Alan Braverman, MD

Cardiologist, Barnes-Jewish & Washington University Heart & Vascular Center


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